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Cardiovascular Research 2006 69(3):559-561; doi:10.1016/j.cardiores.2005.12.011
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Copyright © 2005, European Society of Cardiology

From tadpole tails to transgenic mice: Metalloproteinases have brought about a metamorphosis in our understanding of cardiovascular disease

Andrew C. Newbya,*, Matthias Pauschingerb and Francis G. Spinalec

aBristol Heart Institute, Bristol Royal Infirmary, Bristol BS2 8HW, UK
bKardiologie und Pulmologie, Charité-Medizinische Einrichtungen, Campus Benjamin Franklin, Hindenburgdamm 30, D-12200 Berlin, Germany
cMedical University of South Carolina, 114 Doughty Street, Suite 625, Charleston, South Carolina 29425, USA

* Corresponding author. Tel.: +44 1179283582; fax: +44 1179283581. Email address: a.newby@bris.ac.uk

Received 14 December 2005; accepted 15 December 2005

The first 10% of the full text of this article appears below.

Thirty years ago, most biochemical and molecular science concerned what went on inside cells. Hence, release of enzymes into the extracellular space was seen as important only for specialised functions, such as digestion of nutrients or in blood clotting, events that took place outside solid tissues. Moreover, the discovery of ecto-enzymes–enzymes with their active sites pointing to the extracellular space–was viewed first with scepticism and then largely as a curiosity. Appreciating the full importance of pericellular metabolism for embryogenesis, morphogenesis and cellular regulation needed a revolution in thinking catalysed in significant part by the seminal discovery that resorption of the tadpole . . . [Full Text of this Article]


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