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Cardiovascular Research 2006 69(2):302-303; doi:10.1016/j.cardiores.2005.12.006
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Copyright © 2005, European Society of Cardiology

Soluble guanylate cyclase (sGC) down-regulation by abnormal extracellular matrix proteins as a novel mechanism in vascular dysfunction: Implications in metabolic syndrome

C. Subah Packer*

Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA

* Tel.: +1 317 274 9765; fax: +1 317 274 3318. Email address: spacker1@iupui.edu

Received 23 November 2005; accepted 7 December 2005

The first 10% of the full text of this article appears below.

Vascular dysfunction plays a role in most if not all cardiovascular disorders. Vascular dysfunction is defined as impaired vasodilation in response to agonists such as acetylcholine (ACh) that mediate vascular smooth muscle relaxation through release of the endothelial derived relaxing factor (EDRF) nitric oxide (NO). There is a wealth of literature to support the understanding that endothelial dysfunction is due to a decreased NO synthesis or an increased NO inactivation. Endothelial dysfunction is generally thought to be responsible for vascular dysfunction, and the terms are often used interchangeably. But the mechanism(s) responsible for vascular dysfunction is (are) far from being completely understood, . . . [Full Text of this Article]


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