Copyright © 2005, European Society of Cardiology
Arrhythmogenesis after cell transplantation post-myocardial infarction. Four burning questions–And some answers
Department of Cardiology, University of Ioannina, Greece
* Tel.: +30 265 1097227; fax: +30 265 1097053. Email address: thkolet@cc.uoi.gr
Received 21 November 2005; accepted 7 December 2005
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See article by Fernandes et al. [5] (pages 348–358) in this issue.
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1. Introduction |
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Post-myocardial infarction heart failure remains a major public health problem [1]. Cell transplantation therapy is a promising new therapy, and several studies have shown that transplanted cells can form viable grafts within the host myocardium [2]. Similarly, in small-scale clinical trials, cultured autologous skeletal myoblasts were transplanted into the heart, with significant improvement in contractile indices [3,4]. However, enthusiasm was hampered by possible proarrhythmic effects; within weeks following cell transplantation, ventricular tachycardia or sudden cardiac death occurred in over 40% of patients [3,4].
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2. Is cell transplantation therapy arrhythmogenic? |
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The first ‘burning’ question arises: Does
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3. Does arrhythmogenesis depend on the cell type? |
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4. Possible mechanisms of arrhythmogenesis |
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5. Conclusions |
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