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Cardiovascular Research 2006 69(1):4-6; doi:10.1016/j.cardiores.2005.11.017
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Copyright © 2005, European Society of Cardiology

Insulin: An overall cardiovascular protector?

Yaser Abdallah* and Claudia Schäfer

Institute of Physiology, Justus Liebig University of Giessen, Aulweg 129, 3539, Giessen, Germany

* Corresponding author. Tel.: +49 641 99 47 221; fax: +49 641 99 47 219. Email address: yaser.abdallah@physiologie.med.uni-giessen.de

Received 31 October 2005; accepted 11 November 2005

The first 10% of the full text of this article appears below.

See article by Ma et al. [4] (pages 57–65) in this issue.


   1. Introduction
 
Protection of myocardium against lethal reperfusion injury is one of the major challenges of clinical cardiology today. Many interventions during reperfusion that may influence infarct size or improve cardiac function have been studied experimentally, but none of these has yet found its way into clinical practice. One of the oldest and most discussed interventions to modify reperfusion conditions is the use of glucose–insulin–potassium (GIK) [1], which was reported to reduce the relative in-hospital mortality risk in patients with acute myocardial infarction [2]. . . [Full Text of this Article]


   2. Reperfusion injury of cardiomyocytes and coronary vessels
 
2.1 Insulin-mediated cardiovascular protection

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