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Cardiovascular Research 2006 69(1):1-3; doi:10.1016/j.cardiores.2005.11.011
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Copyright © 2005, European Society of Cardiology

Postconditioning: Reperfusion of "reperfusion injury" after hibernation

David Garcia-Doradoa,* and Hans Michael Piperb

aLaboratorio de Cardiología Experimental, Hospital Universitari Vall d'Hebron, Barcelona, Spain
bInstitute of Physiology, Justus Liebig University, Giessen, Germany

* Corresponding authors. David Garcia-Dorado is to be contacted at Laboratorio de Investigación Cardiovascular Hospital Universitari Vall d'Hebron, Barcelona, Spain. Hans Michael Piper, Institute of Physiology, Justus Liebig University, Aulweg 129 35392 Giessen, Germany. Tel.: +49 641 99 47242; fax: +49 641 99 47209. Email address: dgdorado@hg.vhebron.es michael.piper@physiologie.med.uni-giessen.de

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The newly developed concept of postconditioning as a way of reducing reperfusion injury has been receiving much attention in the literature, both in basic science and clinical circles. Cardiovascular Research will be hosting a Spotlight Issue entitled "Cardiac Protection by Pre- and Postconditioning" in May of this year. This editorial is thought to serve as an introduction to the upcoming issue.

One of the major advances of all times in cardiovascular therapy has been the development and generalization of reperfusion treatment in patients with acute coronary occlusion and evolving myocardial infarction. The experimental basis for that therapy was provided in the early 1980s by the group of Jennings and Reimer at Duke University with the demonstration that early reperfusion can salvage ischemic myocardium that otherwise would die, and that the effectiveness of reperfusion depends . . . [Full Text of this Article]


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