Copyright © 2005, European Society of Cardiology
Questioning the relevance of circulating cardiac progenitor cells in cardiac regeneration
Institute of Experimental and Clinical Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany
* Corresponding author. Tel.: +49 40 42803 7205; fax: +49 40 42803 5925. Email address: w.zimmermann@uke.uni-hamburg.de
Received 14 September 2005; accepted 28 September 2005
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See article by Ausoni et al. [10] (pages 394–404) in this issue.
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1. Introduction |
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Regeneration of injured myocardium would offer relief to millions of patients with left ventricular dysfunction. Cell implantation and induction of stem cell-mediated myocardial self-repair represent potential means to achieve myocardial regeneration [1,2]. The latter requires homing of cardiogenic cells to diseased myocardium or activation of resident cardiogenic stem cells. Both mechanisms have been described in the literature and would be preferable to exogenous cell engraftment with its drawbacks of invasive cell harvesting, cell propagation, and invasive cell deposition in the heart [3–6]. However, recent studies questioned the principal capacity of circulating adult stem cells to give rise to cardiac myocytes and support myocardial regeneration
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2. Finding stem cells in the heart |
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3. Strengths and limitations of the study |
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4. Conclusion |
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