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Cardiovascular Research 2005 68(2):183-185; doi:10.1016/j.cardiores.2005.08.008
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Copyright © 2005, European Society of Cardiology

Complexity of antigenic determinants and humoral responses in vascular injury

Olivier Thaunatb, Guiseppina Caligiurib, Antonino Nicolettib and Jean-Baptiste Michela,*

aInserm Unit 698, Cardiovascular Hematology, Bioengineering and Remodeling, CHU Xavier Bichat, 46 rue Henri Huchard, 75018 Paris, France
bInserm Unit 681, Institut Biomedical des Cordeliers, 75006 Paris, France

* Corresponding author. Email address: jbmichel@bichat.inserm.fr

Received 29 August 2005; revised 29 August 2005; accepted 31 August 2005

The first 10% of the full text of this article appears below.

See article by Shinohara et al. [1] (pages 249–258) in this issue.

Circulating antibodies, reacting with autoantigens in the vascular wall, are commonly harmless in healthy vessels but can turn pathogenic in the presence of vascular injury. The exact antigenic determinants and the role of such autoreactive antibodies remain unclear. In their present study appearing in this issue, Shinohara and coworkers [1] propose a xenogenic, vaccinal experimental approach in order to limit intimal proliferation in response to balloon-induced arterial wall injury in rabbits. Their observations suggest that the observed humoral response is responsible for the limitation of smooth muscle cell (SMC) migration and proliferation via an extracellular effect on the . . . [Full Text of this Article]


   1. Xenoantigens
 

   2. Alloantigens
 

   3. Antibodies in atherosclerosis
 

   4. Conclusions
 

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