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Cardiovascular Research 2005 68(2):175-177; doi:10.1016/j.cardiores.2005.09.002
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Copyright © 2005, European Society of Cardiology

Metabolic therapies for heart disease: Fish for prevention and treatment of cardiac failure?

William C. Stanleya,b,*, Fabio A. Recchiab,c and Isidore C. Okerea

aDepartment of Physiology and Biophysics, and Department of Nutrition, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106-4970, USA
bSector of Medicine, Scuola Superiore Sant' Anna, Pisa, Italy
cDepartment of Physiology, New York Medical College, Valhalla, NY, USA

* Corresponding author. Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106-4970, USA. Tel.: +1 216 368 5585; fax: +1 216 368 3952. Email address: wcs4@case.edu

Received 5 September 2005; accepted 7 September 2005

The first 10% of the full text of this article appears below.

See article by Takahashi et al. [2] (pages 213–223) in this issue.

There are a myriad of structural and biochemical abnormalities associated with the failing heart, yet the hallmark of this syndrome is the inability to effectively transfer the chemical energy from foodstuffs to the mechanical energy of left ventricular ejection against aortic pressure. The causes and consequences of dysfunctional energy metabolism in heart failure are poorly understood; nevertheless, there is growing evidence to suggest that alterations . . . [Full Text of this Article]


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