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Cardiovascular Research 2005 68(1):3-4; doi:10.1016/j.cardiores.2005.07.019
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Copyright © 2005, European Society of Cardiology

C-reactive protein: A potential new molecular link between inflammation, thrombosis and vascular cell proliferation?

Assunta Pandolfi

Aging Research Center, Ce.S.I., "Gabriele D'Annunzio" University Foundation, Department of Biomorphology, University of "G. D'Annunzio", Chieti-Pescara, Italy

Received 14 July 2005; accepted 25 July 2005

The first 10% of the full text of this article appears below.

See article by Cirillo et al. [9] (pages 47–55) in this issue.

C-reactive protein (CRP), a pentraxin synthesized in the liver, is a highly conserved pentameric plasma protein that participates in the systemic response to inflammation. In humans, plasma levels of CRP may rise rapidly and markedly (>1000-fold) after an acute inflammatory stimulus and presumably contribute to host defence [1]. On the other hand, although CRP may exert pleiotropic effects, both "pro-inflammatory" [2] and "anti-inflammatory" (reviewed in Ref. [1]), a large number of studies have demonstrated an . . . [Full Text of this Article]


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