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Cardiovascular Research 2005 68(1):1-2; doi:10.1016/j.cardiores.2005.07.017
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Copyright © 2005, European Society of Cardiology

How much intimacy is compatible with survival for a cardiomyocyte?

Wouter H. Lamersa,* and S. Eleonore Köhlerb

aAMC Liver Center, Academic Medical Center, Meibergdreef 69-71, 1105 BK, Amsterdam, The Netherlands
bDepartment of Anatomy and Embryology, Maastricht University, Maastricht, The Netherlands

* Corresponding author. Email address: w.h.lamers@amc.uva.nl

Received 19 July 2005; accepted 25 July 2005

The first 10% of the full text of this article appears below.

See also article by Driesen et al. (pages 37–46) in this issue.

Most forms of communication between cells occur at the plasma membrane via signal transduction molecules and only indirectly modify the cell's interior. It is easily conceivable that this safeguard is necessary for the cell to maintain the gradient in concentration of biochemical components between its interior and the environment. For similar defensive reasons, extracellular material that is taken up via endocytosis is shuttled to the lysosomes to terminate any inherent biological activity. Most cells, nevertheless, do permit a tightly regulated form of direct communication with other cells, even if they are phenotypically dissimilar, by allowing the formation of gap junctions. Gap junctions . . . [Full Text of this Article]


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