Copyright © 2005, European Society of Cardiology
Forced myocardin expression primes cardiac and smooth muscle transcription patterning in human mesenchymal stem cells
Laboratory of Molecular Biology and Stem Cell Engineering, National Institute of Biostructures and Biosystems, University of Bologna, 40138 Bologna, Italy
* Present address: S. Orsola-Malpighi Hospital, Institute of Cardiology, Via Massarenti N.g, 40138 Bologna, Italy. Tel.: +39 051 6363605; fax: +39 051 344859. Email address: cvent@libero.it
Received 9 May 2005; accepted 10 May 2005
| The first 10% of the full text of this article appears below. |
See article by van Tuyn et al. [7] (pages 245–255) in this issue.
Loss of cardiomyocytes during myocardial infarction or hereditary cardiomyopathies may represent a major determinant in the progression toward heart failure. The reported ability of haematopoietic bone marrow cells to afford myocardial regeneration after direct injection in experimental animals [1] has triggered a number of clinical trials in humans. Nevertheless, the initial observations and the scientific underpinning of the human trials have been challenged by a number of studies using a foreign gene, LacZ or GFP, to
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