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Cardiovascular Research 2005 67(2):179-181; doi:10.1016/j.cardiores.2005.05.026
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Copyright © 2005, European Society of Cardiology

New, emerging roles for cardiac connexins. Mitochondrial Cx43 raises new questions

Stefan Dhein*

Heart Center Leipzig, Clinic for Cardiac Surgery, Struempellstr. 39, 04289 Leipzig, Germany

* Tel.: +49 341 865 1551; fax: +49 341 865 1421. Email address: dhes@medizin.uni-leipzig.de

Received 17 May 2005; accepted 31 May 2005

The first 10% of the full text of this article appears below.

See also article by Boengler et al. [9] (pages 234–244) in this issue.

Connexins are protein subunits that constitute the gap junction channel, a dodecameric channel connecting two neighbouring cells formed by two hexameric hemichannels provided by either cell. The gap junction channel permits intercellular communication by allowing the propagation of the action potential and the transfer of small molecules such as cAMP. Six different gap junctional proteins (connexins; Cx) have been identified in the cardiovascular system: Cx31.9, Cx37, Cx40, Cx43, Cx45, Cx46, Cx50, and Cx57 (the molecular mass in kDa is given by the number) [1,2]. In the heart, there are mainly three isoforms that differ in their molecular weight: connexin 43 (a 43-kDa connexin; Cx43), which is found in most parts of the heart; connexin 40 (Cx40), which is mainly . . . [Full Text of this Article]


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