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Cardiovascular Research 2005 67(2):176-178; doi:10.1016/j.cardiores.2005.05.030
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Copyright © 2005, European Society of Cardiology

Peroxynitrite like Pan?

Nazareno Paolocci*

Division of Cardiology, Johns Hopkins Hospital, Baltimore, MD, USA

* 835 Ross Bldg, 720 Rutland Avenue, Baltimore, MD 21205, USA. Tel.: +1 1 410 955 4813; fax: +1 1 410 502 2558. Email address: npaoloc1@jhmi.edu

Received 24 May 2005; accepted 31 May 2005

The first 10% of the full text of this article appears below.

See also article by Borbély et al. [9] (pages 225–233) in this issue.

Peroxynitrite is a reactive nitrogen species (RNS) generated by the rapid, diffusionally controlled reaction of nitric oxide (NO) and superoxide [1]. Its formation has been implicated in many pathophysiological conditions such as ischemia–reperfusion, sepsis, and congestive heart failure (CHF). Nitrotyrosine formation has been claimed as a "footprint" for peroxynitrite presence and induced damage. This alteration is due to covalent protein modification derived from the addition of a nitro (–NO2) group onto one of the equivalents on the carbons of the aromatic rings of tyrosine residues (NO2Tyr) [2]. Nitrotyrosine production is not only indicative of oxidative/nitrosative stress, but is also a process whereby many proteins might be post-translationally modified. Protein function, catalytic activity, . . . [Full Text of this Article]


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