Copyright © 2005, European Society of Cardiology
Studying mechanisms underlying shedding of endothelial membrane proteins could help patients at risk for myocardial infarction
University of Bristol, Bristol Heart Institute, Bristol Royal Infirmary, Bristol BS2 8HW, United Kingdom
* Tel.: +44 1179283582; fax: +44 1179283581. Email address: A.Newby@bristol.ac.uk
Received 19 April 2005; accepted 20 April 2005
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See article by Singh et al. [8] (pages 39–49) in this issue
The single, most prevalent cause of premature death in the developed world is myocardial infarction, with more than 1 million occurrences each in Europe and the United States each year. For almost half of its victims, it is the first sign of coronary artery disease and, for a third, it is fatal. There is, therefore, an urgent need to define biomarkers to identify healthy individuals at high risk for myocardial infarction. These patients can then be targeted for aggressive risk factor reduction by established lifestyle and pharmacological approaches. There is also an emerging possibility of preventive