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Cardiovascular Research 2005 65(2):302-304; doi:10.1016/j.cardiores.2004.11.023
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Copyright © 2004, European Society of Cardiology

Arrhythmogenic right ventricular dysplasia type 1 and mutations in transforming growth factor β3 gene regulatory regions: a breakthrough?

Stanley Nattela,* and Jean-Jacques Schottb

aResearch Center and Department of Medicine, Montreal Heart Institute and University of Montreal, 5000 Belanger St. E., Montreal, Quebec, Canada H1T 1C8
bINSERM U-533 and l'Institut du Thorax, University of Nantes, Nantes, France

* Corresponding author. Tel.: +1 514 376 3330; fax: +1 514 376 1355. Email address: stanley.nattel@icm-mhi.org

Received 16 November 2004; accepted 18 November 2004

The first 10% of the full text of this article appears below.

See article by Beffagna et al. (pages 366–373) in this issue.

Arrhythmogenic right ventricular dysplasia (ARVD) is the second most common cause of sudden unexpected death in young adults [1], responsible for ~20% of sudden deaths in this population [2]. Subsequent to the description of the first case in 1961 [3], great progress has been made in the diagnosis, evaluation and management of the condition. The hallmark of ARVD is right ventricular atrophy with fibro-fatty infiltration. There is approximately threefold male predominance, and typical abnormalities include signs of right ventricular thinning and dysfunction and fragmented, low-amplitude . . . [Full Text of this Article]


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S. Sen-Chowdhry, P. Syrris, and W. J. McKenna
Role of Genetic Analysis in the Management of Patients With Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy
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[Abstract] [Full Text] [PDF]