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Cardiovascular Research 2005 65(2):293-295; doi:10.1016/j.cardiores.2004.11.031
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Copyright © 2004, European Society of Cardiology

Bone marrow cells for cardiac regeneration: the quest for the protagonist continues

Buddhadeb Dawn* and Roberto Bolli

From the Institute of Molecular Cardiology, University of Louisville, ACB, 3rd Floor 550 South Jackson Street, Louisville, KY 40292, USA

* Corresponding author. Tel.: +1 502 852 7959; fax: +1 502 852 7147. Email address: buddha@louisville.edu

Received 22 November 2004; accepted 30 November 2004

The first 10% of the full text of this article appears below.

See also article by Hattan et al. [11] (pages 334-344) in this issue.


   1. Introduction
 
The past few years have witnessed an explosion of research on methods to achieve myocardial repair via cellular transplantation or mobilization of endogenous cells [1]. Several different cell types, including skeletal myoblasts [2], c-kit+/Sca-1+/lin– bone marrow (BM) cells [3], BM mesenchymal stem cells (MSCs) [4], BM ‘side-population’ (SP) cells [5], endothelial progenitor cells (EPCs) [6], and cardiac stem cells (CSCs) [7], have been utilized in an effort to achieve cardiac reconstitution and restoration of function following myocardial infarction (MI). The evidence accumulated over the past few years indicates that left ventricular (LV) function and adverse LV remodeling can be . . . [Full Text of this Article]


   2. The ideal cell for therapeutic use
 

   3. Regeneration of the vasculature
 

   4. The existence of ‘tissue-committed stem cells’ (TCSCs) in the BM
 

   5. Future directions
 

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