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Cardiovascular Research 2005 65(1):8-9; doi:10.1016/j.cardiores.2004.10.027
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Copyright © 2004, European Society of Cardiology

On the cardiovascular activity of apelin

Gianni A. Losano*

Sezione di Fisiologia, Università di Torino, Corso Raffaello, 30, 10125 Torino, Italy

* Tel.: +39 11 6707785; fax: +39 11 670 7708. Email address: gianni.losano@unito.it

Received 14 October 2004; accepted 21 October 2004

The first 10% of the full text of this article appears below.

See article by Ashley et al. [8] (pages 73–82) in this issue.

Apelin, a peptide recently isolated from bovine stomach extracts, has been seen to act as an endogenous ligand of the orphan G-protein-coupled APJ receptor [1]. The structure of apelin preproteins was deduced from the sequences of the relevant cDNAs. The preproteins consist of 77 amino acid residues, with the apelin active sequence in the C-terminal regions [1]. Apelin mRNA expression was also found in the gastrointestinal tract, adipose tissue, brain, lung, kidney, liver, skeletal muscle, and cardiovascular system. In the cardiovascular system, it has been detected in endothelial cells of large conduit arteries, coronary vessels, and endocardium of the right atrium [2].

Apelin displays several activities on various systems. . . . [Full Text of this Article]


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