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Cardiovascular Research 2005 65(1):6-7; doi:10.1016/j.cardiores.2004.11.002
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Copyright © 2004, European Society of Cardiology

Understanding the molecular and cellular basis of therapeutic stem and progenitor cell transplantation for tissue revascularization

Ioakim Spyridopoulos*

Clinical and Molecular Cardiology, Department of Internal Medicine IV, Johann Wolfgang Goethe University of Frankfurt, Theodor-Stern Kai 7, 60590 Frankfurt am Main, Germany

* Tel.: +49 69 6301 7387, +49 69 6301 5749; fax: +49 69 6301 6546. Email address: spyridopoulos@em.uni-frankfurt.de

Received 1 November 2004; revised 2 November 2004; accepted 2 November 2004

The first 10% of the full text of this article appears below.

See also article by Li et al. [6] (pages 64–72) in this issue.

The primary goal of therapy for patients with acute myocardial infarction is rapid revascularization of ischemic tissue. Since thrombolytic therapy or catheter-based intervention can only accomplish so much initially, new strategies are desirable to salvage already injured tissue and restore organ function. A decade ago, several researchers developed and refined the concept of therapeutic angiogenesis by gene therapy, either through the application of cDNA-encoding plasmids or by local injection of the desired protein [1]. . . . [Full Text of this Article]


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