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Cardiovascular Research 2004 64(3):384-386; doi:10.1016/j.cardiores.2004.09.015
© 2004 by European Society of Cardiology
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Copyright © 2004, European Society of Cardiology

The fine-scale architecture of defibrillation

Arun V. Holden*

Computational Biology Laboratory, School of Biomedical Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom

* Tel.: +44 113 343 4251; fax: +44 113 343 4230. Email address: arun@cbiol.leeds.ac.uk

Received 12 September 2004; accepted 20 September 2004

The first 10% of the full text of this article appears below.

See article by Sharifov et al. (pages 448–456) in this issue


   1. Introduction
 
Ventricular fibrillation is fatal, unless it self-terminates or is terminated by an intervention. It probably is partially responsible for most non-violent deaths and is the immediate cause of death in most sudden cardiac deaths, which form up to a fifth of adult premature deaths in the developed world [1]. The only effective treatment is prompt defibrillation by a brief, large-amplitude electrical shock that produces a field of more than 5 V/cm in the myocardium. Since DC cardiac defibrillation/cardioversion was pioneered by Lown [2] in the 1960s, there have been substantial improvements in the engineering of defibrillators, leading to implantable devices for high-risk patients and public access automatic defibrillators in public areas [1,3]. However, the cellular and tissue electrophysiological . . . [Full Text of this Article]


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