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Cardiovascular Research 2004 64(2):189-191; doi:10.1016/j.cardiores.2004.08.010
© 2004 by European Society of Cardiology
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Copyright © 2004, European Society of Cardiology

Caveolae and EDHF production

Jeremy D. Pearson*

Cardiovascular Division, King's College London, Guy's Campus, London SE1 1UL, UK

* Tel.: +44 20 7848 6210; fax: +44 20 7848 6220. Email address: jeremy.pearson@kcl.ac.uk

Received 10 August 2004; accepted 18 August 2004

The first 10% of the full text of this article appears below.

See article by Graziani et al. [8] (pages 234–242) in this issue.

It has been recognised for just over 50 years that endothelial cells possess abundant invaginated plasma membrane structures with a limited size range (50–100 nm diameter), first characterised by electron microscopy and suspected to be vesicles involved in transcytosis, delivering macromolecules from plasma to the subendothelium. With the recognition of the specific architecture of the vesicles they were named caveolae ("little caves") and the major protein responsible for maintaining the basket or flask shape of the vesicles was identified in the early 1990s and named caveolin-1 [1]. Caves are well known in fairy tales to contain treasure, and the unfolding story of caveolae has already yielded many treasures.

. . . [Full Text of this Article]


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