Skip Navigation

Cardiovascular Research 2004 63(2):189-191; doi:10.1016/j.cardiores.2004.06.008
© 2004 by European Society of Cardiology
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Eberli, F. R
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Eberli, F. R
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Copyright © 2004, European Society of Cardiology

Stunned myocardium—an unfinished puzzle

Franz R Eberli*

Cardiovascular Center, University Hospital Zurich, Rämistrasse 100, 8091 Zurich, Switzerland

* Tel.: +41-1-255-33-97, +41-1-255-22-16; fax: +411-255-44-01. Email address: franz.eberli@usz.ch

Received 7 June 2004; accepted 9 June 2004

The first 150 words of the full text of this article appear below.

See article by Colantonio et al. [15] (pages 217–225) in this issue.

Myocardial stunning describes the phenomenon of reversible contractile dysfunction of viable myocardium after restoration of normal or nearly normal epicardial coronary flow following myocardial ischemia. In man, myocardial stunning has been observed following cardiac surgery (global ischemia and reperfusion), in myocardial infarction after timely reperfusion therapy (regional prolonged severe ischemia and reperfusion with stunned myocardium around areas of necrosis), in unstable angina and coronary spasm (regional transient ischemia without or with minimal necrosis), and in exercise-induced angina (demand ischemia with almost normal blood flow). Recurrent episodes of stunning might result in hibernating myocardium [1,2]. The designs of experiments used to elucidate the cellular and molecular mechanisms involved in myocardial stunning were as heterogeneous as the clinical settings involved in this phenomenon.

Oxygen-free radicals and intracellular calcium overload have been identified as two pathogenetic mechanisms inducing intracellular damage . . . [Full Text of this Article]


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?