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Cardiovascular Research 2004 62(3):442-443; doi:10.1016/j.cardiores.2004.03.013
© 2004 by European Society of Cardiology
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Copyright © 2004, European Society of Cardiology

Ghrelin in the heart and growth hormone: which is chicken, which is egg?

Françoise Pecker*

INSERM Unité 581, Hôpital Henri Mondor 94010 Créteil, France

* Tel.: +33-149-813534; fax: +33-148-980908. Email address: pecker@im3.inserm.fr

Received 5 March 2004; accepted 10 March 2004

The first 10% of the full text of this article appears below.

In their study published in this issue, Iglesias et al. give the first evidence that ghrelin is synthesized and secreted by cardiomyocytes. Ghrelin is a 28-amino acid peptide containing an n-octanoyl modification at serine 3. It acts on the pituitary and hypothalamus to stimulate growth hormone (GH) release, food intake, and adiposity. It has been newly identified as the endogenous ligand of the orphan GH secretagogues (GHS) receptor, GHSR-1a, that is mostly expressed in pituitary and hypothalamus. Acylation of ghrelin is required for activation of GHSR-1a, whereas des-acyl ghrelin, which is far more abundant than ghrelin, does not bind GHSR-1a and is devoid of any endocrine activity [1,2].

GH and its mediator, insulin-like growth factor (IGF)-1, are anabolic hormones that . . . [Full Text of this Article]


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