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Cardiovascular Research 2004 62(3):439-441; doi:10.1016/j.cardiores.2004.03.022
© 2004 by European Society of Cardiology
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Copyright © 2004, European Society of Cardiology

Calcium cycling in heart failure: how the fast became too furious

Anne-Sophie Armand and Leon J De Windt*

Hubrecht Laboratory and Interuniversity Cardiology Institute Netherlands, Royal Netherlands Academy of Arts and Sciences, Uppsalalaan 8, Utrecht 3584 CT, The Netherlands

* Corresponding author. Tel.: +31-30-212-1800; fax: +31-30-212-1801. Email address: dewindt@niob.knaw.nl

Received 15 March 2004; accepted 22 March 2004

The first 10% of the full text of this article appears below.

See article by Yanczewski et al. [11] (pages 468–480) in this issue.

...After them, the (scientific) philosophers appear...who proclaim that only they are wise and all other mortals are but shadows flapping about. ... [The philosophers] build uncountable worlds as ...they hypothesize without hesitation causes for ...unexplainable things, as if they were secretaries of Nature, architects of all things, as if they appeared among us from a meeting of gods. Meanwhile, Nature laughs at them and their speculations, because that they have uncovered nothing is demonstrated by the fact that they immediately cross their swords on each single issue without results...

From Moriae Encomium (the Praise of Folly) by Desiderius Erasmus (1509 AD).

For the maintenance of cardiac function, there may be no more important molecule than calcium. During each heartbeat, a small leak of calcium through the voltage-dependent L-type . . . [Full Text of this Article]


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