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Cardiovascular Research 2004 61(4):651-652; doi:10.1016/j.cardiores.2004.01.001
© 2004 by European Society of Cardiology
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Copyright © 2004, European Society of Cardiology

Is cardiac IKs a relevant drug target?

Michael J Curtis*

Cardiovascular Research, The King's Centre for Cardiovascular Biology and Medicine, The Rayne Institute, St Thomas' Hospital, London, SE1 7EH, UK

* Tel.: +44-207-928-9292x2330; fax: +44-207-922-8139. michael.curtis@kcl.ac.uk

Received 22 December 2003; accepted 2 January 2004

The first 10% of the full text of this article appears below.

See article by Nakashima et al. (pages 705–714) in this issue.

It is with pleasure that I write a commentary on a new work from Stanley Nattel's laboratory. Nakashima et al. (Cardiovascular Research, this issue) have examined the actions of a relatively selective IKs blocker on a variety of cardiac electrophysiological variables in anesthetized dogs. There is an important underlying question driving this work, namely: to what extent does IKs represent a potential target for modulation of cardiac rhythm by drugs? Modulation, it should be noted, encompasses pro-arrhythmic as well as antiarrhythmic actions.

Since the first full characterization of IKs as . . . [Full Text of this Article]


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