© 2004 by European Society of Cardiology
Copyright © 2004, European Society of Cardiology
Cytosolic prostaglandin E2 synthase/p23 but not apoptosis-linked gene 2 is downregulated in human atherosclerotic plaques
aDivision of Pharmacology, University of Antwerp, Universiteitsplein 1, B-2610 Wilrijk, Belgium
bDepartment of Pathology, A.Z. Middelheim, Antwerp, Belgium
* Corresponding author. Tel.: +32-3-820-27-10; fax: +32-3-820-25-67. wim.martinet@ua.ac.be
Received 12 November 2003; accepted 14 November 2003
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In the November issue of Cardiovascular Research, we reported a strong downregulation of apoptosis-linked gene 2 (ALG-2) protein in advanced human atherosclerotic plaques as compared with non-atherosclerotic mammary arteries [1]. Because ALG-2 is a positive mediator of apoptosis, we proposed a novel