© 2003 by European Society of Cardiology
Copyright © 2003, European Society of Cardiology
Transcription factors for ion channels: active or passive players in cardiac remodeling?
Department of Pharmacology and Toxicology, Dresden University of Technology, Fetscher Str 74, 01307 Dresden, Germany
*Tel.: +49-351-458-6279; fax: +49-351-458-6315. Email address: dobrev@rcs.urz.tu-dresden.de
Received 4 September 2003;
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Chronic cardiac disease is associated with structural, mechanical, and electrical remodeling processes that comprise activation of numerous signal transduction pathways [1]. In hypertrophy and heart failure, for instance, electrical remodeling consists of prolongation of the ventricular action potential duration that may be interpreted as an acquired long-QT syndrome and hence may explain the propensity for ventricular arrhythmias. In myocardial biopsies from these patients, the transient outward current Ito is significantly down-regulated and this is associated with a lower expression of mRNA for the corresponding ion channel subunits (in man predominantly Kv4.3, in rat predominantly Kv4.2; Ref. [2]).
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