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Cardiovascular Research 2003 59(3):536-537; doi:10.1016/S0008-6363(03)00501-7
© 2003 by European Society of Cardiology
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Copyright © 2003, European Society of Cardiology

Does the Na+,K+ pump current undergo remodeling in atrial fibrillation?

Edward Carmeliet*

University of Leuven, Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium

edward.carmeliet@med.kuleuven.ac.be

* Tel.: +32-16-402-823; fax: +32-16-347-139.

Received 24 June 2003; accepted 26 June 2003

The first 10% of the full text of this article appears below.

See article by Workman et al. [1] (pages 593–602) in this issue.

The sodium pump current has been the subject of many studies, but information on human cardiac tissue is lacking. This gap has been filled by a paper published in this issue in which Workman, Kane and Rankin [1] describe the maximal capacity and functional characteristics of the Na+,K+ pump current (Ip) in atrial cells from patients with and without chronic atrial fibrillation (AF). The main conclusions are that the pump current contributes to the resting potential and the duration of the action potential. Sensitivity to the external K+ concentration, [K+]e, and the voltage dependence of the pump do not change in AF. The authors conclude that Ip is not involved in AF-induced . . . [Full Text of this Article]


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