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Cardiovascular Research 2003 59(3):532-533; doi:10.1016/S0008-6363(03)00504-2
© 2003 by European Society of Cardiology
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Copyright © 2003, European Society of Cardiology

Building better blood vessels: new insight on the molecular control of arteriogenesis

Arthur R Strauch*

Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, College of Medicine and Public Health, 473 West 12th Avenue, Room 503, Columbus, OH 43210-1252, USA

strauch.1@osu.edu

* Tel.: +1-614-292-3147; fax: +1-614-292-4888.

Received 1 July 2003; accepted 1 July 2003

The first 10% of the full text of this article appears below.

See article by Boengler et al. [2] (pages 573–581) in this issue.

Our understanding of the initial steps in blood vessel formation has been advanced through studies employing transgenic and knock-out mouse models [1] as well as isolated cells cultivated under conditions of altered oxygen level and shear stress. From the standpoint of identifying basic biological controls, examination of the tumor vascularization process also has provided insight concerning the molecular pathways required to form and sustain the microvasculature. However, much remains to be discovered about the far slower, adaptive process of arteriogenesis whereby pre-existing arterioles adopt new structural features required for sustaining blood flow around vascular obstructions. Especially fascinating are . . . [Full Text of this Article]


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