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Cardiovascular Research 2003 58(3):495-497; doi:10.1016/S0008-6363(03)00369-9
© 2003 by European Society of Cardiology
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Copyright © 2003, European Society of Cardiology

Structural correlates of electrical remodeling in ventricular hypertrophy

Hanumanth K. Reddy*, Sanjeev Wasson, Santhosh K.G. Koshy and Ravi Komatireddy

Division of Cardiology and Department of Internal Medicine, University of Missouri Hospital, Columbia, MO, USA

reddyh@health-missouri.edu

* Corresponding author. 318 McHaney Hall, University of Missouri Hospital, 1 Hospital Drive, Columbia, MO, USA. Fax: +1-573-884-7743.

Received 2 March 2003; accepted 1 April 2003

The first 10% of the full text of this article appears below.

See article by Peschar et al. [2] (pages 510–517) in this issue.

Ventricular remodeling is an adaptive change in cardiac chamber structure and function in response to volume and/or pressure overload. In the last few years, it became clear that this process also involves the electrical system of the ventricular chambers. Electrical remodeling associated with left ventricular hypertrophy and heart failure causes an increased frequency of ventricular ectopy and a high risk of cardiac arrest. The degree of electrical remodeling and arrhythmic risk is not directly proportional to the severity of left ventricular (LV) dysfunction. For example, in the VHeFT study (Veterans Administration Heart Failure Trial), the risk of sudden cardiac death was greater in . . . [Full Text of this Article]


    1 Correlation of electrical remodeling with structural remodeling
 

    2 Unanswered questions and future goals
 

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