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Cardiovascular Research 2003 58(2):241-245; doi:10.1016/S0008-6363(03)00317-1
© 2003 by European Society of Cardiology
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Copyright © 2003, European Society of Cardiology

Spotlight on stem cells—makes old hearts fresh

Marcel A.G. van der Heydena,*, Jürgen Heschelerb and Christine L. Mummeryc

aDepartment of Medical Physiology, University Medical Center Utrecht, P.O. Box 85060, 3508 AB Utrecht, The Netherlands
bDepartment of Neurophysiology, University of Cologne, Robert-Koch-Str. 39, 50931 Köln, Germany
cHubrecht Laboratory, Netherlands Institute of Developmental Biology, Uppsalalaan 8, 3584 CT, The Netherlands

m.a.g.vanderheyden@med.uu.nl

* Corresponding author. Tel.: +31-30-253-8418; fax: +31-30-253-9036.

Received 21 February 2003; accepted 22 February 2003

The first 150 words of the full text of this article appear below.

...makes old hearts fresh... A winter's tale; William Shakespeare


   1 Historical perspective
 
Is there a better way to restore function of a damaged organ than simply by replacing it?

The idea of transplantation has caught the imagination throughout history, leading to the creation of mythological figures like the sphinx, mermaids and centaurs; all examples of xenotransplantation. Centuries later, transplantation fantasy and technology came into the hands of the medical profession, with Mary Shelley's Frankenstein (1818) being an extreme example from classical literature, which, fortunately, does not reflect clinical results of those times.

Modern stem cell based transplantation in humans originates in blood and bone marrow research. In the late 19th century, the concept of blood forming stem cells was formed [1–3]. This important concept was further studied and elaborated in the next decades by, among others, Pappenheim and Ferrata. The first therapeutic use of bone marrow was described in 1896. Here, bone . . . [Full Text of this Article]


   2 Introduction to the reviews and original contributions
 
2.1 Embryonic development and phenotyping
2.2 Stem cell sources and models, differentiation and characterization
2.3 Stem cell transplantation

   3 Future perspectives
 

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