Sodium and the heart: a hidden key factor in cardiac regulation

doi:10.1016/S0008-6363(02)00849-0

Cardiovascular Research 2003 57(4):871-872; doi:10.1016/S0008-6363(02)00849-0
© 2003 by European Society of Cardiology

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Sodium and the heart: a hidden key factor in cardiac regulation

Burkert Pieske^a^,*, Steven R Houser^b, Gerd Hasenfuss^a and Donald M Bers^c

^aDepartment of Cardiology and Pneumology, University of Göttingen, Göttingen, Germany
^bMolecular and Cellular Cardiology Laboratories, Temple University School of Medicine, Philadelphia, PA 19140, USA
^cDepartment of Physiology, Loyola University Chicago, Maywood, IL 60153, USA

pieske@med.uni-goettingen.de

^* Corresponding author. Tel.: +49-551-3989-25; fax: +49-551-3919-127.

The first 10% of the full text of this article appears below.

Myocyte Na⁺ homeostasis is crucially involved in a number ofvital cell functions, such as excitability, excitation–contractioncoupling, energy metabolism, pH regulation, as well as cardiacdevelopment and growth. However, consideration of Na⁺ regulationis often relegated to a secondary position in the discussionof cardiac (patho-)physiology, where the focus is typicallyon contractile proteins, Ca²⁺ regulation and pH regulation whichappear more directly related to contractile function. However,myocyte Na⁺ homeostasis is as complex as Ca²⁺ or pH homeostasisand [Na⁺. . . [Full Text of this Article]

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