© 2003 by European Society of Cardiology
Copyright © 2003, European Society of Cardiology
Collagen cross-linking: new dimension to cardiac remodeling
University of Missouri—Columbia, Columbia, MO, USA
koshys@health.missouri.edu
* Corresponding author. DC 034.00, Division of Cardiology, University of Missouri—Columbia, 1 Hospital Drive, Columbia, MO 65212, USA. Tel.: +1-573-882-2296; fax: +1-573-884-7743.
| The first 150 words of the full text of this article appear below. |
See article by Badenhorst et al. [1] (pages 632–641) in this issue.
Left ventricular (LV) dysfunction has become a leading area of research as the prevalence of heart failure is reaching epidemic proportions. LV chamber remodeling and stiffness are consequent to significant structural and functional alteration of both the myocyte and extracellular matrix (ECM). Both these factors are important determinants of chamber size and geometry as well as its contractile and relaxation properties. Numerous papers have been published about the seminal role of collagen concentration and collagenolysis in hypertrophic and dilated cardiomyopathies; however, the qualitative aspects of these changes were not correlated well with the functional characteristics of cardiac chambers. In this issue of Cardiovascular Research, Baldenhorst et al. [1] show the influence of collagen cross-linking on chamber stiffness and remodeling.
Cellular mechanisms responsible for transformation of compensatory myocardial hypertrophy to a dysfunctional dilated ventricle remain enigmatic. Earlier studies
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Collagen cross-linking and chamber stiffness |
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Collagen cross-linking and cardiac remodeling |
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Other novel factors involved in cardiac remodeling |
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Future implications |
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