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Cardiovascular Research 2002 56(3):357-358; doi:10.1016/S0008-6363(02)00713-7
© 2002 by European Society of Cardiology
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Copyright © 2002, European Society of Cardiology

Cardiac differentiation of mesenchymal stem cells in sex mis-matched transplanted hearts: self-repair or just a visit?

Heinrich Sauer*, Jürgen Hescheler and Maria Wartenberg

Department of Neurophysiology, University of Cologne, Robert-Koch-Str. 39, D-50931 Cologne, Germany

heinrich.sauer@uni-koeln.de

* Corresponding author. Tel.: +49-221-478-6976; fax: +49-221-344-527

Received 2 October 2002; accepted 2 October 2002

The first 10% of the full text of this article appears below.

See article by Bayes-Genis et al. [10] (pages 404–410) in this issue.

Currently, a paradigm shift from the widely accepted dogma of the heart being incapable of self-repair is occurring. This is mostly owing to recent revolutionary observations that host-derived stem cells, presumably mesenchymal stem cells derived from the bone marrow, can be recruited to, encraft within the myocardium and may participate in the regeneration of heart function [1–3]. The apparent plasticity of adult stem cells has prompted the possibility that bone marrow-derived mesenchymal cells could be isolated from patients, sub-cultivated in vitro and reintroduced after occurrence of heart disease. Bone marrow cells and cardiomyocytes . . . [Full Text of this Article]


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