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Cardiovascular Research 2002 56(3):332-338; doi:10.1016/S0008-6363(02)00643-0
© 2002 by European Society of Cardiology
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Copyright © 2002, European Society of Cardiology

Personal reflections on efforts to reduce ischemic myocardial damage

Eugene Braunwald*

Department of Medicine, Harvard Medical School and Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA

* Tel.: +1-617-732-8989; fax: +1-617-975-0955. ebraunwald@partners.org

Received 14 August 2002; accepted 20 August 2002

The first 150 words of the full text of this article appear below.


   1 Background
 
In the second half of the 19th Century, physiologists observed that ligation of a major coronary artery in the dog was immediately fatal. During that era, pathologists occasionally encountered thrombosis of such vessels and acute myocardial infarction (AMI) at autopsy, and considered this combination of findings to be quite uncommon and uniformly fatal. At the dawn of the twentieth century, Krehl, a Viennese physician, challenged these beliefs and reported that coronary thrombosis was actually compatible with survival [1]. In 1910, Obrastov and Strazheske [2], two Russian physicians, and in 1912, Herrick, a Chicago physician [3], described the clinical features of AMI, related them to the pathologic findings and distinguished AMI from angina pectoris. Herrick also adapted the then new technique of electrocardiography to the premorbid diagnosis of AMI, considered at the time to be a very uncommon condition.

By the middle of the 20th Century, during my . . . [Full Text of this Article]


   2 Early research
 

   3 The reduction of ischemia by carotid nerve stimulation
 

   4 Early efforts to reduce ischemic damage
 

   5 Clinical myocardial reperfusion
 

   6 The TIMI trials
 

   7 Stunning and hibernation
 

   8 ACE inhibitors and statins
 

   9 Conclusions
 

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