Cardiovascular Research 2002 56(1):1-3; doi:10.1016/S0008-6363(02)00605-3
© 2002 by European Society of Cardiology
Copyright © 2002, European Society of Cardiology
Triggers and promoters of ischaemic preconditioning
Division of Cardiology and Department of Internal Medicine, University of Missouri Hospital, Columbia, MO 65212, USA
* Corresponding author. Tel.: +1-573-882-2640; fax: +1-573-884-7743.
Received 26 July 2002; accepted 26 July 2002
| The first 10% of the full text of this article appears below. |
See article by Wang et al. [10] (pages 33–42) in this issue.
Ischaemia/reperfusion injury in coronary artery disease patients confers increased morbidity and mortality due to pump dysfunction and arrhythmia. In cardiac patients, ischaemic episodes still occur in an unpredictable manner despite multiple drug therapies and revascularization strategies. Therefore, unrelenting efforts in the way of ischaemic preconditioning have been underway to devise treatment modalities for preparing the heart to face ischaemia in a more benign (ischemia can never be benign) manner.
Ischaemic preconditioning describes the