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Cardiovascular Research 2002 55(3):425-428; doi:10.1016/S0008-6363(02)00488-1
© 2002 by European Society of Cardiology
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Copyright © 2002, European Society of Cardiology

Spotlight on preconditioning

Derek M Yellon* and James M Downey

University College Hospital, Academic and Clinical Cardiology Department, Hatter Institute for Cardiovascular Sciences, Grafton Way, London WC1E 6DB, UK

hatter-institute@ucl.ac.uk

* Corresponding author. Tel.: +44-207-380-0591; fax: +44-207-388-5095

Received 17 May 2002; accepted 17 May 2002

The first 150 words of the full text of this article appear below.

The phenomenon of ischaemic preconditioning, in which a period of sublethal ischemia can profoundly protect the cell from subsequent lethal ischemic insult, has without doubt been responsible for an enormous amount of research over the last 15 years. Since the original publication in 1986 by Murry et al. [1] there have been in excess of 2000 publications directly attributed to this phenomenon. Furthermore it is virtually impossible to find a publication that fails to demonstrate the ability of sublethal ischemia to protect the myocardium from a lethal ischemic insult thus attesting to the power of the phenomenon of ischemic preconditioning. This early form of protection has become know as "classic or early preconditioning". This was followed in 1993 by the first description of the "Second Window of Protection" or delayed preconditioning (sometimes referred to as late preconditioning) by Marber et al. [2] in which a second period of protection was . . . [Full Text of this Article]


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