© 2002 by European Society of Cardiology
Copyright © 2002, European Society of Cardiology
The wnt-frizzled cascade in cardiovascular disease
aDepartment of Pharmacology, Cardiovascular Research Institute Maastricht, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands
bDepartment of Pathology, Cardiovascular Research Institute Maastricht, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands
* Corresponding author. Tel.: +31-43-388-1417; fax: +31-43-388-4149 wm.blankesteijn@farmaco.unimaas.nl
Received 22 June 2001; accepted 17 December 2001
KEYWORDS Angiogenesis; Developmental biology; Infarction; Signal transduction
| The first 150 words of the full text of this article appear below. |
 |
1. Introduction |
|---|
Wnt-proteins constitute a family of secreted cystein-rich glycosylated proteins, involved in a variety of modeling and remodeling processes including cell proliferation, differentiation, apoptosis and the control of cell orientation [1–3]. Malfunctioning of the wnt-frizzled pathway has been implied in diseases as divergent as cancer and Alzheimer's disease [1,4]. The wnt-frizzled signal transduction pathway plays an important role during non-vertebrate and vertebrate development [5]. Several studies have shown the importance of wnts in the control of processes such as patterning of the body axis and development of the central nervous system and the limbs [6,7]. Moreover, interventions in wnt signaling have been described to affect cardiac morphogenesis [8,9] and several members of the wnt-frizzled signal transduction pathway were found to be expressed during cardiac development in vertebrates [10–14].
In cardiovascular pathology, re-expression of a fetal gene expression pattern is a generally observed phenomenon [15]. The
|
2. Brief outline of the wnt-frizzled cascade |
|---|
|
3. The wnt-frizzled pathway and cardiac wound healing after myocardial infarction |
|---|
|
4. The wnt-frizzled cascade and angiogenesis/neovascularization |
|---|
|
5. The wnt-frizzled cascade, cardiac hypertrophy and heart failure |
|---|
|
6. The wnt-frizzled cascade and arterial injury |
|---|
|
7. Conclusions |
|---|
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  L. Wang, D. Gesty-Palmer, T. A. Fields, and R. F. Spurney Inhibition of WNT Signaling by G Protein-Coupled Receptor (GPCR) Kinase 2 (GRK2) Mol. Endocrinol., September 1, 2009; 23(9): 1455 - 1465. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. GAO, Z. XU, M.-S. HUNG, Y.-C. LIN, T. WANG, M. GONG, X. ZHI, D. M. JABLON, and L. YOU Promoter Demethylation of WIF-1 by Epigallocatechin-3-gallate in Lung Cancer Cells Anticancer Res, June 1, 2009; 29(6): 2025 - 2030. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. L. Clifford, K. Deacon, and A. J. Knox Novel Regulation of Vascular Endothelial Growth Factor-A (VEGF-A) by Transforming Growth Factor {beta}1: REQUIREMENT FOR Smads, {beta}-CATENIN, AND GSK3{beta} J. Biol. Chem., December 19, 2008; 283(51): 35337 - 35353. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Christman II, D. J. Goetz, E. Dickerson, K. D. McCall, C. J. Lewis, F. Benencia, M. J. Silver, L. D. Kohn, and R. Malgor Wnt5a is expressed in murine and human atherosclerotic lesions Am J Physiol Heart Circ Physiol, June 1, 2008; 294(6): H2864 - H2870. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Jovanovic, A.-S. Dugast, J.-M. Heslan, J. Ashton-Chess, M. Giral, N. Degauque, A. Moreau, A. Pallier, E. Chiffoleau, D. Lair, et al. Implication of Matrix Metalloproteinase 7 and the Noncanonical Wingless-Type Signaling Pathway in a Model of Kidney Allograft Tolerance Induced by the Administration of Anti-Donor Class II Antibodies J. Immunol., February 1, 2008; 180(3): 1317 - 1325. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Roura, F. Planas, C. Prat-Vidal, R. Leta, C. Soler-Botija, F. Carreras, A. Llach, L. Hove-Madsen, G. P. Llado, J. Farre, et al. Idiopathic dilated cardiomyopathy exhibits defective vascularization and vessel formation Eur J Heart Fail, October 1, 2007; 9(10): 995 - 1002. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Mirotsou, Z. Zhang, A. Deb, L. Zhang, M. Gnecchi, N. Noiseux, H. Mu, A. Pachori, and V. Dzau Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair PNAS, January 30, 2007; 104(5): 1643 - 1648. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Brade, J. Manner, and M. Kuhl The role of Wnt signalling in cardiac development and tissue remodelling in the mature heart Cardiovasc Res, November 1, 2006; 72(2): 198 - 209. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. S. Barth, R. Kuner, A. Buness, M. Ruschhaupt, S. Merk, L. Zwermann, S. Kaab, E. Kreuzer, G. Steinbeck, U. Mansmann, et al. Identification of a Common Gene Expression Signature in Dilated Cardiomyopathy Across Independent Microarray Studies J. Am. Coll. Cardiol., October 17, 2006; 48(8): 1610 - 1617. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K.-i. Kim, H.-J. Cho, J.-Y. Hahn, T.-Y. Kim, K.-W. Park, B.-K. Koo, C. Soo Shin, C.-H. Kim, B.-H. Oh, M.-M. Lee, et al. {beta}-Catenin Overexpression Augments Angiogenesis and Skeletal Muscle Regeneration Through Dual Mechanism of Vascular Endothelial Growth Factor-Mediated Endothelial Cell Proliferation and Progenitor Cell Mobilization Arterioscler Thromb Vasc Biol, January 1, 2006; 26(1): 91 - 98. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Uren, S. Fallen, H. Yuan, A. Usubutun, T. Kucukali, R. Schlegel, and J. A. Toretsky Activation of the Canonical Wnt Pathway during Genital Keratinocyte Transformation: A Model for Cervical Cancer Progression Cancer Res., July 15, 2005; 65(14): 6199 - 6206. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. You, B. He, Z. Xu, K. Uematsu, J. Mazieres, N. Fujii, I. Mikami, N. Reguart, J. K. McIntosh, M. Kashani-Sabet, et al. An Anti-Wnt-2 Monoclonal Antibody Induces Apoptosis in Malignant Melanoma Cells and Inhibits Tumor Growth Cancer Res., August 1, 2004; 64(15): 5385 - 5389. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Masuelli, R. Bei, P. Sacchetti, I. Scappaticci, P. Francalanci, L. Albonici, A. Coletti, C. Palumbo, M. Minieri, R. Fiaccavento, et al. {beta}-Catenin accumulates in intercalated disks of hypertrophic cardiomyopathic hearts Cardiovasc Res, November 1, 2003; 60(2): 376 - 387. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Schafer, D. Abraham, P. Paulus, R. Blumer, M. Grimm, J. Wojta, and S. Aharinejad Impaired VE-Cadherin/{beta}-Catenin Expression Mediates Endothelial Cell Degeneration in Dilated Cardiomyopathy Circulation, September 30, 2003; 108(13): 1585 - 1591. [Abstract] [Full Text] [PDF]
|
|