© 2002 by European Society of Cardiology
Copyright © 2002, European Society of Cardiology
Repolarization abnormalities in heart failure
aDepartment of Experimental Cardiology, Experimental and Molecular Cardiology Group, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
bDepartment of Cardiology, Heart Lung Center Utrecht, Utrecht, The Netherlands
r.coronel@amc.nl
* Tel.: +31-20-566-3267
Received 15 January 2002; accepted 18 January 2002
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See article by Lacroix et al. [1] (pages 42–50) in this issue.
The paper by Lacroix et al., published in this issue of Cardiovascular Research, is of interest because it deals with the question of mechanisms underlying sudden arrhythmic death in patients with heart failure [1]. This is a problem of great clinical significance, because increasing numbers of patients are suffering from heart failure and are at risk of sudden cardiac death [2], especially at moderate degrees of failure [3].
Heart failure is extremely difficult to study experimentally, not only because it is difficult to define [4], but also because a