© 2002 by European Society of Cardiology
Copyright © 2001, European Society of Cardiology
New tools for prevention of restenosis could decrease the oculo-stento reflex
aDepartment of Physiology, School of Medicine, MA415 Medical Sciences Building, University of Missouri, Columbia, MO 65212, USA
bDepartment of Internal Medicine, Division of Cardiology, School of Medicine, University of Missouri, Columbia, MO 65212, USA
cDiabetes & Cardiovascular Biology Program, School of Medicine, University of Missouri, Columbia, MO 65212, USA
* Corresponding author. Tel.: +1-573-882-2640 or 573-882-3787; fax: +1-573-884-4276 sturekm@missouri.edu
accepted 7 December 2001
KEYWORDS Restenosis; Stents; Angioplasty; Atherosclerosis
| The first 10% of the full text of this article appears below. |
See article by Yasuda et al. [8] (pages 481–486) in this issue.
Restenosis remains the major challenge to percutaneous coronary intervention procedures, despite substantial improvements. Standard balloon angioplasty results in restenosis in 30–50% of patients within several months after successful revascularization [1], requiring repeat target vessel revascularization. Placement of stents effectively reduces early restenosis due to elastic recoil of the artery, but there is increased late restenosis due to excessive intimal hyperplasia, yielding an overall restenosis rate of about 20–30% [2]. Although this restenosis
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