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Cardiovascular Research 2002 53(1):6-8; doi:10.1016/S0008-6363(01)00518-1
© 2002 by European Society of Cardiology
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Copyright © 2001, European Society of Cardiology

An ion channel ‘addicted’ to ether, alcohol and cocaine: the HERG potassium channel

Christoph A Karle* and Johann Kiehn

Department of Cardiology, University of Heidelberg Medical School, Bergheimerstraße 58, D-69115 Heidelberg, Germany

* Corresponding author. Tel.: +49-6221-568-682; fax: +49-6221-565-515 christoph.karle@gmx.de

Received 26 October 2001; accepted 26 October 2001

The first 10% of the full text of this article appears below.

See article by O'Leary [25] (pages 59–67) in this issue.

In cardiomyocytes, the rapid component of the delayed rectifier K+ current, IKr [1,2], plays an important role in repolarization. During the plateau phase, IKr has only a small amplitude; this function of IKr supports the formation of the plateau potential and is a consequence of its inwardly rectifying properties. As repolarization proceeds, a transient increase in IKr outward current occurs, due to fast recovery from inactivation and slow deactivation, which effectively repolarizes the cardiac cell [3].

On the molecular level, IKr is encoded by the ‘human ether-a-go-go related gene’ (HERG). This has been . . . [Full Text of this Article]


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