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Cardiovascular Research 2001 52(3):517-518; doi:10.1016/S0008-6363(01)00482-5
© 2001 by European Society of Cardiology
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Copyright © 2001, European Society of Cardiology

Considerations in studying the transient outward K+ current in cells exhibiting the hyperpolarization-activated current

Arie O Verkerka,* and Antoni C.G van Ginnekenb

aDepartment of Physiology, Academic Medical Center, University of Amsterdam, Room M01-09, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
bExperimental and Molecular Cardiology Group, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands

* Corresponding author. Tel.: +31-20-566-4670; fax: +31-20-691-9319 a.o.verkerk@amc.uva.nl

Received 5 June 2001; accepted 14 September 2001

The first 10% of the full text of this article appears below.

Recently, we focussed our research on cellular electrophysiological changes involved in the modulated sinoatrial (SA) node function during heart failure [1] and aging [2]. Heart failure and age-dependent changes of ionic membrane currents, especially the transient outward K+ current (Ito1), are well documented in working myocardium [3,4]. Therefore, we read with interest the paper in Cardiovascular Research by Lei et al. [5], on the characterization of Ito1 in rabbit SA node cells. In their paper, Lei et al. [5] determined (1) the properties of Ito1, (2) the . . . [Full Text of this Article]


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