Skip Navigation

Cardiovascular Research 2001 52(2):171-173; doi:10.1016/S0008-6363(01)00454-0
© 2001 by European Society of Cardiology
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Shivkumar, K.
Right arrow Articles by Weiss, J. N
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Shivkumar, K.
Right arrow Articles by Weiss, J. N
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Copyright © 2001, European Society of Cardiology

Atrial fibrillation: from cells to computers

Kalyanam Shivkumara,* and James N Weissb

aCardiac Electrophysiology Section, Division of Cardiology, Department of Medicine, University of Iowa Hospitals and Clinics, 4426 B, JCP, 200 Hawkins Drive, Iowa City, IA 52242-1081, USA
bUCLA Cardiovascular Research Laboratory, Departments of Medicine (Cardiology) and Physiology, UCLA School of Medicine, Los Angeles, CA 90095, USA

* Corresponding author. Tel.: +1-319-384-6105; fax: +1-319-384-6247 kalyanam-shivkumar@uiowa.edu

accepted 6 September 2001

The first 150 words of the full text of this article appear below.

See article by Workman et al. [11] (pages 226–235) in this issue.

Atrial fibrillation is one of the commonest arrhythmias encountered in clinical practice. The incidence of this arrhythmia increases with age and it is responsible for substantial morbidity, mortality [1]. Numerous studies have been performed to elucidate the cellular and molecular events associated with this rhythm. Our conceptual framework for understanding this rhythm disturbance is based on the pioneering work of Gordon Moe [2]. Atrial fibrillation is thought to be due to repetitive activation of the atria by multiple reentrant wavelets. Subsequent experimental work confirmed the key elements of the hypothesis of Moe [1]. The exact origin and the behavior of such wavelets is a source of intense ongoing investigation utilizing experimental and computational approaches.


   1. Cellular electrophysiological changes due to AF
 
The cellular ionic changes that allow repetitive activation of the atria at such high rates have been the focus of several . . . [Full Text of this Article]


   2. The present study
 

   3. Intra-atrial and inter-atrial heterogeneity in action potential characteristics
 

   4. What are the implications of such studies?
 

   5. Future questions
 

Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?