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Cardiovascular Research 2001 52(1):1-4; doi:10.1016/S0008-6363(01)00417-5
© 2001 by European Society of Cardiology
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Copyright © 2001, European Society of Cardiology

Function and structure of the mouse sinus node: nothing you can see that isn’t shown

Tobias Opthof*

Department of Medical Physiology, University Medical Center Utrecht, PO Box 85060, 3508 AB Utrecht, The Netherlands

* Tel.: +31-30-253-8923; fax: +31-30-253-9036 t.opthof@med.uu.nl

Received 25 July 2001; accepted 25 July 2001

The first 150 words of the full text of this article appear below.

See articles by Verheijck et al. [1] (pages 40–50) and Mangoni and Nargeot [2] (pages 51–64) in this issue.

In this issue of Cardiovascular Research two papers are published on the mouse sinus node [1,2]. One is about the activation pattern, the characteristics of the leading pacemaker area and the connexions connecting the sinus node cells with each other and with the surrounding atrial working myocardium [1]. The other paper focuses on the individual membrane currents in single cells isolated from the sinus node including the effects of noradrenaline and acetylcholine [2].


   1 Structure
 
The structure of the mouse heart in late fetal stages was recently described in a paper by Webb et al. [3], but the term ‘sinus node’ was missing in this paper. From this perspective the paper by Verheijck et al. [1] fills a gap in our knowledge on the structure of the murine sinus . . . [Full Text of this Article]


   2 Function
 

   3 Intercellular coupling
 

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