© 2001 by European Society of Cardiology
Copyright © 2000, European Society of Cardiology
Plasma A- and B-type natriuretic peptides: physiology, methodology and clinical use
Internal Medicine/Cardiovascular Research Institute COEUR, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
* Corresponding author. University Hospital Dijkzigt, Internal Medicine, Rm L-276, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands. Tel.: +31-10-463-3764; fax: +31-10-463-4531 boomsma@inw1.azr.nl
Received 17 November 2000; accepted 20 December 2000
KEYWORDS Natriuretic peptide; Atrial function; Ventricular function
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1 Introduction |
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In the 20 years which have passed since the first description by de Bold of a natriuretic and diuretic substance produced in the heart [1], a large body of research has firmly established the position of the heart as an endocrine organ. Two peptides, both containing a 17-amino acid ring structure, have been a focus of much interest: atrial natriuretic peptide (ANP), and brain (or B-type) natriuretic peptide (BNP). A third member of this family of peptides, C-type natriuretic peptide, has been described; it is mainly produced by the endothelium and not by the heart, has no diuretic or natriuretic activity, and will not be discussed here.
ANP is produced mainly in the cardiac atria, while BNP, originally isolated from porcine brain, was soon reported to be mainly produced in the cardiac ventricles. In recent years, however, it has become clear that in fact both ANP and BNP are
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2 Physiological effects of ANP and BNP |
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3 Methodology |
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3.1 Blood sampling conditions
3.2 Measurement
3.3 Stability
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4 Use of natriuretic peptide measurements |
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4.1 Congestive heart failure (CHF)
4.2 Acute coronary syndromes
4.3 Right ventricular overload
4.4 Renal failure
4.5 Hypertension
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5 Pharmacological manipulation |
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