© 2001 by European Society of Cardiology
Copyright © 2001, European Society of Cardiology
Transmural dispersion of repolarization and the T wave
Masonic Medical Research Laboratory, 2150 Bleecker Street Utica, New York, NY 13501, USA
* Tel.: +1-315-735-2217; fax: +1-315-735-5648 ca@mmrl.edu
Received 13 March 2001; accepted 13 March 2001
| The first 150 words of the full text of this article appear below. |
See article by Taggart et al. [50] (pages 454-462) in this issue.
Studies conducted over the past dozen years or so have demonstrated that ventricular myocardium is not homogeneous, as previously thought, but is comprised of at least three electrophysiologically distinct cell types: epicardial, M and endocardial cells (see [1,2] for reviews). These three cell types have also been shown to possess different pharmacologic profiles and to respond differently to a variety of pathophysiologic states [3–8].
The three cells types differ principally with respect to repolarization characteristics. Ventricular epicardial and M cells display action potentials with a prominent transient outward current (Ito)-mediated phase 1, giving rise to a notched appearance of the action potential. The absence of a prominent notch in the endocardium is a consequence of a much smaller Ito. Similar regional differences in Ito are found in canine, feline, rabbit, rat and human ventricular
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