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Cardiovascular Research 2001 50(3):419-422; doi:10.1016/S0008-6363(01)00284-X
© 2001 by European Society of Cardiology
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Copyright © 2001, European Society of Cardiology

Defining heart failure

R Coronela,*, J.R de Groota and J.J van Lieshoutb

aTaskforce for Heart Failure and Aging, Experimental and Molecular Cardiology Group, Department of Clinical and Experimental Cardiology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
bTaskforce for Heart Failure and Aging, Department of Internal Medicine, Academic Medical Center, Meibergdreef 9, room M053, 1105 AZ Amsterdam, The Netherlands

* Corresponding author. Tel.: +31-20-566-3267; fax: +31-20-697-5458 r.coronel@amc.nl

The first 150 words of the full text of this article appear below.

The definition of heart failure is hampered by the wide variability of the clinical symptoms and signs, and of their etiologies. Many attempts have been made to come up with a general set of criteria that describe heart failure [1–7]. These criteria include clinical, epidemiological, pathophysiological, and exercise-related criteria and criteria derived from the patient's response to therapy. The need for a more circumscript definition reflects the hope to be able to stratify patient groups, to detect heart failure at an earlier stage and to optimally treat patients. At the basis of this need is our wish to understand heart failure as a pathogenetic entity. Moreover, to attain this purpose a clear definition is required for the design of adequate experimental protocols.

From medical history we know that the understanding of diseases often has started with the recognition of consistency in a set of symptoms and signs. The starting . . . [Full Text of this Article]


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