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Cardiovascular Research 2001 50(1):3-6; doi:10.1016/S0008-6363(01)00218-8
© 2001 by European Society of Cardiology
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Copyright © 2001, European Society of Cardiology

On the trail of cardiac specific transcription factors

Markus Flesch*

Winters Center for Heart Failure Research, Baylor College of Medicine, VA Medical Center, Bldg. 110, 2002 Holcombe Blvd., Houston, TX 77030, USA

* Tel.: +1-713-794-7949; fax: +1-713-794-7770 mflesch@bcm.tmc.edu

accepted 7 February 2001

The first 150 words of the full text of this article appear below.

See article by Dellow et al. [1] (pages 24–33) in this issue.


   1 Introduction
 
Transcription factors are the last link in signaling cascades regulating gene transcription. An increasing number of transcription factors have been described over the last years, and for many genes, essential transcription factor binding regions have been identified. The detailed understanding of the promoter regions essential for gene transcription and the different transcription factors, which are involved in promoter activation, is one of the scientific challenges of this decade and a prerequisite for targeted interventions in gene expression. In this context, the discovery of organ and gene specific transcription factors are of particular interest.

In this issue of Cardiovascular Research [1], the group of Paul J.R. Barton reports on recent progress in their efforts to define the essential activation sites of the human cardiac troponin I promoter. This promoter is interesting for cardiovascular research because troponin I is . . . [Full Text of this Article]


   2 Sp transcription factor family
 

   3 GATA transcription factor family
 

   4 MEF2 transcription factor family
 

   5 HCB1 and HCB2 as potential new cardiac specific transcription factors
 

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