Skip Navigation

Cardiovascular Research 2000 47(4):637-639; doi:10.1016/S0008-6363(00)00161-9
© 2000 by European Society of Cardiology
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Cross, H. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cross, H. R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Copyright © 2000, European Society of Cardiology

Trimetazidine: a novel protective role via maintenance of Na+/K+-ATPase activity?

Heather R. Cross*

Department of Pathology, Box 3712, Duke University Medical Center, Durham, NC 27710, USA

* Tel.: +1-919-541-5411; fax: +1-919-541-3385 laszlo.deszi@richter.hu

Received 14 June 2000; accepted 26 June 2000

The first 10% of the full text of this article appears below.

See article by El Banani et al. [31] (pages 688–696) in this issue.

Trimetazidine (1-[2,3,4-trimethoxybenzyl]-piperazine; TMZ) is a piperazine compound that has been demonstrated to protect against ischaemic injury in a variety of tissues [1–4]. As a cardiovascular therapeutic agent, TMZ is protective during coronary artery bypass graft surgery [5] and catheter angioplasty [6], has been effective in the treatment of angina [7,8] and reduces infarct size when given before thrombolysis in patients with anterior myocardial infarction [9]. There have been insights into some of the molecular mechanisms of action of TMZ, however, new mechanisms continue to be discovered [10–12]. The best known action of . . . [Full Text of this Article]


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?