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Cardiovascular Research 2000 47(1):6-8; doi:10.1016/S0008-6363(00)00080-8
© 2000 by European Society of Cardiology
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Copyright © 2000, European Society of Cardiology

The hibernators heart

Nature's response to arrhythmogenesis?

Tobias Opthof* and Martin B Rook

Department of Medical Physiology, University Medical Center, PO Box 80043, 3508 TA Utrecht, The Netherlands

* Corresponding author. Tel.: +31-30-253-8900; fax: +31-30-253-9036 t.opthof@med.uu.nl

Received 20 March 2000; accepted 23 March 2000

The first 10% of the full text of this article appears below.

See article by Saitongdee et al. [1] (pages 108–115) in this issue.


   1 Introduction
 
In this issue, Saitongdee et al. [1] describe an increase in connexin43, the major constituent of gap junctions in ventricular muscle [2], in hamsters (Mesocricetus auratus) exposed to circumstances that provoke hibernation of the animals. The hamsters were subjected to a temperature of 5°C in combination with 2 h of light per 24 h during a period of 8–10 weeks after a gradual transition from normal conditions to hypothermia. During control conditions the temperature was 20°C with a 8:16-h light/dark circadian photoperiod. Reduction of temperature and light period was 1°C and 30 min per day, respectively. . . . [Full Text of this Article]


   2 Conduction at low temperature
 

   3 Hibernators: paradigma of adaptation to arrhythmogenesis
 

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[Abstract] [Full Text] [PDF]