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Cardiovascular Research 2000 46(3):367-369; doi:10.1016/S0008-6363(00)00085-7
© 2000 by European Society of Cardiology
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Copyright © 2000, European Society of Cardiology

Cardiac microdialysis a powerful tool

Keith Jackson, Martin Farias and James L. Caffrey*

Department of Integrative Physiology, Cardiovascular Research Institute, University of North Texas Health Science Center, Fort Worth, TX 76107, USA

* Corresponding author. Tel.: +1-817-735-2085; fax: +1-817-735-5084 jcaffrey@hsc.unt.edu

Received 27 March 2000; accepted 27 March 2000

The first 10% of the full text of this article appears below.

See article by Akiyama et al. [1] (pages 531–538) in this issue.

Tsuyoshi Akiyama and Toji Yamazaki have reported that norepinephrine inhibits acetylcholine release from post-ganglionic cardiac vagal efferents [1]. This is hardly a novel idea since the existence of pre-junctional adrenergic receptors, presumably located on cardiac parasympathetic efferents, has been well documented both physiologically and pharmacologically. What is unique here is that the authors have actually measured steady-state changes in acetylcholine within the interstitium of the working left ventricle. They have done this with an elegant marriage of in situ microdialysis and an ultra-sensitive HPLC-electrochemical detection system.

The report referenced above represents another step forward in the continuing struggle to evaluate the paracrine environment within the myocardium. Much of the early work in this regard was focused on quantifying the dynamics of capillary filtration including the osmotic contribution . . . [Full Text of this Article]


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